I think if you scrape away the obvious differences, such as Thanos being a mutant born on Titan with enhanced strength and other physicals and the purple skin, there is still very little similarities between the two. Thanos's hatred and disregard for human life grew gradually as he grew up, compared to Dexter's which occurred when he witnessed what happened in the containment unit. Admittedly in the Thanos Rising storyline his mother tries to kill him however no violence actually occurred. There is also the fact that to everyone else Dexter is just a normal guy, he hides the killer inside of him, which is the complete opposite of Thanos, who also does so on a much grander scale.
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