It has been revealed for X-Factor #227 that one team mate will be killed: http://marvel.com/comic_books/issue/37946/x-factor_2005_227

So who will it be that kicks the bucket and will they even stay dead with Layla's power?

I think that the woman of X-Factor are safe from being killed, because there are 4 of them to the 5 guys on the team and with Havok and Polaris joining the team after Regenesis killing one of the men will allow the team to become gender balanced with 5 of either gender. Of the men, Madrox is safe, because he appears in X-Factor #229 as a witness to his and Layla's death (http://dewaynes-world.popshop.comixology.com/item/OCT110682/X-Factor-229-Xregg). Strong Guy is also safe because he was already killed on a recent case and later brought back by Layla. That leaves Rictor, Shatterstar, and Longshot. Ric won't be killed because he just got his powers back in Children's Crusade and that would make his getting his powers back redundant. So my prediction for who will die is that it's going to be either Shatterstar or Longshot, with odds favouring Longshot because his powers are being blocked somewhat by Bloodbath.

Another possiblility is that Pip 'ports in just in time to get killed, but I don't think that this is very likely.

However, I also believe that Layla will be forced to use her powers to bring the team mate back, which fits with all 11 characters on the cover of X-Factor #230 (http://i.newsarama.com/images/XMenRegenesis-gold-final-massive.jpg).