Hmm...Cage and Wise both have steel hard/ultra dense skin and super strength. However...Luke Cage should be able to win this one. Cage is older, more experienced, and hell of a lot stronger than Wise Son. But I'd have to give it to Wise Son. Wise have other abilities beside being invincible and super strong.
During the Wise Son limited series, while holding her hand, Wise was able to extend his invulnerability powers to his girlfriend so she could survive a shoot out. In the Milestone Forever limited series, while holding Holocaust hands, Wise was able to make Holocaust vulnerable and unable to survive the heat from his own Pyrokinesis power.
Cage has better hand to hand skills and will beat on Wise like he stole something on them Harlem streets. Wise don't have the strength to go back and fourth with Cage. Granted the hits won't hurt him but he'd have to hate getting punch and thrown by Cage. I think Wise, while getting his a$$ whooped, would manage to grab a hold of Cage to make him vulnerable and then proceed to kick his @ss with no regard until he is beaten and unconscious to win the fight. Now if it was just steel hard skin dude vs steel hard skin dude Cage would win but because of Wise other powers, I'll give him the slight edge.
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