Mr Sinister

Bullseye

Red Skull

Loki

Carnage

Tiger Shark

Mephisto

Of the ones you listed it comes down to the Red Skull and Mephisto.

I'd say Mephisto.

Gotta go with Red Skull, most other villains have a decent excuse for the **** they do, while he's just a racist monster.

good point, but is he actually any worse than, say, Apocalypse in that regard? or Cassandra Nova?

or someone completely nihilistic like Sabertooth. He'll eat ya, just 'cause.

yep, yep he is.

how so?

Actually it's been stated that Red Skull isn't racist (by either Captain America or Red Skull himself, I forget which) but he was alined with the Nazi party simply to be able to further his own goals.

tiger shark? really? really?........................ mephisto.

Mole Man:

from the lIst I would personally say carnage even tho hes not my favorIte vIllaIn he kIlls kust for the sake of kIllIng everyone else up there eIther has a plan or reason for what they do. plus now that carnage Is In complete control after the mInImum carnage arc he wIll most lIkely be more vIle

Green Goblin maybe.....from one point,he's dedicated his life in destroying Spider-Man....