Wesker wins. Slade has better strength and skill feats, but Wesker wins due to his speed and healing factor. Wesker is fast enough to casually dodge bullets almost at the level of Neo and Agents from the Matrix, fast enough to speed blitz Alice (who was fully powered by the T-virus) on the airplane and stick her with the cure needle, has a healing factor powerful enough to survive a plane crashing into a mountain at full speed, and after having his brains blown out the back of his head with a point blank shotgun blast he started to get up after about 25 seconds. Also, in his fight against the Redfields (Chris and Claire) and Alice, keep in mind that Wesker was trying not to hurt them. He needed to keep them alive so he could feed on their DNA to keep the T-virus from taking control over him.
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